Nitric Oxide, Vascular Health & Longevity: Inside the Deep Six Podcast with Berkeley Life’s Chief Science Officer

Nitric Oxide, Vascular Health & Longevity: Inside the Deep Six Podcast with Berkeley Life’s Chief Science Officer

Featuring Dr. James Lewerenz and Cathy Eason, MS, FNTP – Chief Science Officer, Berkeley Life

Why Nitric Oxide May Be the Missing Link in How We Age

What if one molecule could impact your energy, heart health, metabolism, brain, digestion, sexual wellness, and longevity? That molecule is Nitric Oxide (NO) — and it’s the focus of a powerful new episode of The Deep Six Podcast, hosted by Dr. James Lewerenz, featuring Cathy Eason, Chief Science Officer of Berkeley Life.

In this episode, Dr. Lewerenz and Cathy break down why Nitric Oxide is key to healthy aging — and why declining NO levels may drive fatigue, higher blood pressure, and reduced vitality after age 40.

What Is Nitric Oxide (and Why It Matters)

Nitric Oxide is a short-lived gas produced naturally in the body — but its effects are massive:

  • Relaxes muscles and blood vessels

  • Improves blood flow and oxygen delivery

  • Supports vascular health

But it’s more than a “blood flow molecule.” As Cathy explains, Nitric Oxide is a master signaling molecule that affects nearly every system in the body.

The Aging Problem: NO Declines After 40

By age 40, up to 50% of Nitric Oxide production is lost — and it keeps declining with age. Factors like oxidative stress, inflammation, hormones, and genetics accelerate the drop.

For women, perimenopause and menopause make this decline even sharper, contributing to:

  • Rising blood pressure

  • Lower stamina and slower recovery

  • Brain fog and fatigue

  • Metabolic issues

  • Changes in sexual wellness

How to Support Nitric Oxide Naturally

Nitric Oxide can be made in two ways:

  1. Enzyme pathway – using arginine and citrulline (less effective with age)

  2. Dietary nitrate pathway – from leafy greens, beets, and arugula

Berkeley Life focuses on the dietary nitrate pathway because it:

  • Bypasses aging enzymes

  • Supports oral bacteria that convert nitrates to NO

  • Provides a longer-lasting Nitric Oxide boost

Clinical studies show:

  • 28% improvement in circulation in 12 weeks

  • ~10% reduction in blood pressure

  • Elevated NO levels for 24+ hours

The Oral Microbiome Connection

Your mouth plays a critical role:

  • Certain oral bacteria turn nitrates into usable Nitric Oxide

  • Mouthwash can disrupt this process

  • Saliva recycles NO throughout the day

Nitric Oxide works system-wide — not just in one area.

The Top Benefits of Optimizing Nitric Oxide

  1. Heart & Blood Pressure Support – healthier vessels, lower pressure

  2. Energy & Recovery – better oxygen delivery, performance, and stamina

  3. Metabolic Health – improved blood sugar control and flexibility

  4. Digestive Health – supports gut motility and barrier function

  5. Brain & Mood – boosts focus, clarity, and stress balance

  6. Sexual Wellness – enhanced blood flow, arousal, and performance

What’s Next: Nitric Oxide Research in Women’s Health

Berkeley Life is advancing studies on:

  • Perimenopausal & postmenopausal women

  • Heart rate, blood pressure, and inflammation

  • Blood sugar, sleep, cognition, and mood

  • Physical performance and VO₂ max

The Takeaway: Longevity Starts with Nitric Oxide

Supporting Nitric Oxide isn’t about fixing one symptom — it’s about protecting the system that keeps every other system running. Energy, heart health, metabolism, sexual wellness, and long-term vitality all start here.

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