CLINICAL SCIENCE & RESEARCH
Science-Backed Solutions, Powered by Nitric Oxide
Our formulations are supported by clinical research, peer-reviewed studies, and ongoing scientific rigor into Nitric Oxide and whole-body health.
12,000+ clinical research articles on Nitric Oxide Science
Trusted by 3,000+ Healthcare Providers
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Validated in a randomized, double-blind, placebo-controlled clinical trial
Built on Research. Designed for Real Outcomes.
40
Years of Biomedical Research
On Nitric Oxide A Nobel Prize-winning molecule
3
Published Clinical Studies
Supporting Berkeley Life formulations
4
Additional Studies
Currently in progress
3,000+
Healthcare Providers
Trust Berkeley Life
More Than Ingredients. Proven Outcomes.
At Berkeley Life, clinical validation goes beyond individual ingredients.
Our formulations are evaluated through human clinical research measuring outcomes like blood pressure, endothelial function, circulation, NO bioavailability, and sexual wellness.
Our patented 15-second saliva strips were used in our clinical research alongside laboratory testing, where strip readings tracked lab-measured nitrite levels. The same marker, readable at home.
Our practitioner partners recommend Berkeley life for blood pressure support,sexual health and helping to support blodd flow. Our consumers consistantly report improvement in energy levels
Our patented 15-second saliva strips were used in our clinical research alongside laboratory testing, where strip readings tracked lab-measured nitrite levels. The same marker, readable at home.
FEATURED STUDY
Nitric Oxide Support Clinical Trial
Conducted with The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. It's a vascular function trial.
Participants supplementing with Berkeley Life Nitric Oxide Support experienced significant improvements in blood pressure, endothelial function, circulation, and nitric oxide bioavailability compared to placebo.
STUDY TYPE
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED
DURATION
12 WEEKS
PRIMARY ENDPOINT
BLOOD PRESSURE REDUCTION
SECONDARY ENDPOINTS
FMD, ENDOTHELIAL FUNCTION, NITRATE/NITRITE LEVELS
INSTITUTION
HARBOR-UCLA MEDICAL CENTER
PUBLICATION
CLINICAL NUTRITION ESPEN
NITRIC OXIDE BIOAVAILABILITY
Berkeley Life vs. Placebo
Systolic and Diastolic BP changes
-12.5 MM/HG
SYSTOLIC
PLACEBO
Statistically significant · Source: Clinical Nutrition ESPEN, 2020
Measured against placebo
Blood pressure reduction was the endpoint this trial set out to test. The bars show the result against a placebo group over 12 weeks. That placebo comparison is what makes the difference meaningful. The reduction is attributable to the formula itself.
- Randomized
- Double-Blind
- Placebo-Controlled
- 12 Weeks
FEATURED STUDY
Nitric Oxide 24-Hour Duration
Conducted with the Department of Kinesiology at the University of Virginia. It's a pharmacokinetics trial.
Following a single dose, participants showed peak salivary and plasma nitrate/nitrite levels within 2 hours — and sustained elevation of nitric oxide precursors lasting a full 24 hours.
STUDY TYPE
OPEN-LABEL, PHASE 1, SINGLE-ARM
DURATION
SINGLE DOSE, SAMPLED OVER 24 HOURS
PRIMARY ENDPOINT
SALIVARY & PLASMA NITRATE/NITRITE PHARMACOKINETICS
SECONDARY ENDPOINTS
PEAK CONCENTRATION TIMING, SALIVA TEST STRIP CORRELATION
INSTITUTION
UNIVERSITY OF VIRGINIA
PUBLICATION
JOURNAL OF CLINICAL MEDICINE (MDPI)
NITRIC OXIDE BIOAVAILABILITY
378% nitrate
Where the curve peaks, and where it holds
The study tracked how fast nitrate reaches the blood and how long it stays there. 378% is the rise above each participant's own starting level, measured at the two hour peak. The tail matters more. Levels were still elevated at hour 24, which is what a once daily dose provides to optimize bioavailability.
- OPEN-LABEL
- PHASE 1
- SINGLE-ARM
- 24H SAMPLING
FEATURED STUDY
Nitric Oxide Female Sexual Health
An unpublished pilot study exploring the effects of a plant-based bioequivalent inorganic nitrate formula. It's an intimacy study.
Participants reported meaningful gains in libido and orgasm over 60 days of daily use — including women concurrently on hormone replacement therapy.
STUDY TYPE
PILOT STUDY (UNPUBLISHED)
DURATION
60 DAYS
PRIMARY ENDPOINT
FEMALE SEXUAL FUNCTION (LIBIDO, AROUSAL, ORGASM)
SECONDARY ENDPOINTS
SEXUAL DISCOMFORT, COMPATIBILITY WITH HRT
AUTHOR
J. ALLEN (2024)
PUBLICATION
UNPUBLISHED MANUSCRIPT
SELF-REPORTED OUTCOMES
Share Of Participants Reporting Improvement
Read this as an early signal
A 60-day pilot in a small group of women, average age 60. The results are self-reported, there was no control group, and the work has not been peer reviewed. The numbers point at something worth testing properly, not at a proven effect.
A separate 30-day randomised trial of the same formula is described in the linked article. That one had a placebo group.
- Pilot study
- Unpublished
- 60 days
Pathway Comparison
Choosing a Nitric Oxide Protocol: How the Options Compare
Providers ask how Berkeley Life compares to other Nitric Oxide approaches. The table below answers the questions we hear most — and gives honest credit to other categories where it's clinically warranted. What differentiates Berkeley Life is the combination of a finished-formula RCT, a patented saliva test system, and a complete practice protocol.
| Clinical Criterion | Berkeley LifeDietary nitrate capsule | Sodium Nitrite Lozenges | Beetroot Gummies & Chews | L-Arginine / L-Citrulline | Beetroot Powder / Juice |
|---|---|---|---|---|---|
| Primary NO pathway |
Dietary nitrate — entero-salivary conversion
|
Direct sodium nitrite → NO
|
Dietary nitrate, often paired with polyphenol vasodilators (grape seed extract)
|
L-arginine and/or L-citrulline
|
Dietary nitrate — entero-salivary conversion
|
| Form delivered |
Dietary nitrate — the form found in leafy greens and beets
|
Sodium nitrite — an already-reduced nitrite intermediate
|
Concentrated beetroot plus grape seed extract in a chewable matrix
|
Amino acid substrate for the body's NOS enzyme
|
Dietary nitrate within a whole-food matrix
|
| Onset & duration of NO support |
Sustained -- 2 hour peak onset & sustained by gradual conversion via oral bacteria; NO support over 24 hours
|
Rapid onset, short-acting bolus
|
Sustained via the nitrate pathway; typical serving delivers a lower nitrate dose than clinical protocols
|
Variable; dose- and enzyme-dependent
|
Sustained; dose-variable
|
| Age-independent efficacy |
✓Pathway functions at every age
|
✓Bypasses NOS
|
✓Pathway functions at every age
|
NOS activity declines with age
|
✓Pathway functions at every age
|
| Finished-formula RCT |
✓Randomized, double-blind, 12-week trial — Lundquist Institute at Harbor-UCLA (2020)
|
Older & smaller studies
|
Brand-sponsored studies on combined formulas; smaller in scale
|
Strong ingredient evidence; few branded-formula RCTs
|
Ingredient-level research only
|
| Saliva test-and-measure system |
✓Patented NO saliva test strips
|
✓Strips available from some brands
|
Not offered
|
Not offered
|
Not offered
|
| Patient experience & tolerability |
Capsule; no oral sensation; well-tolerated daily
|
Lozenge must dissolve in the mouth; some patients report oral burning or tingling, flushing, or transient headache from rapid vasodilation
|
Palatable chew format; typically contains added sugars or sugar alcohols; occasional GI effects or beeturia
|
GI upset common at therapeutic doses
|
Taste and GI effects; beeturia common
|
- Well-supported
- Partial / mixed evidence
- Not offered
APPLY NOW
Submit Your Research Proposal
FOR RESEARCHERS & INSTITUTIONS ONLY
This is a research application, not a consumer store.
Our team reviews all proposals within 10 business days. Fill out the form below — and let's advance the science together.
Good to Know
Before you submit, here's what to expect.
10 business days
Average review turnaround
Confidential review
Your research details are protected
No IRB required to apply
But required before product ships
Ships direct
To your research site or institution
Grad students welcome
With faculty advisor on file
Questions before submitting?
research@berkeleylife.com
Explore the Research
Scientific Advisory board
Behind every Berkeley Life formula is peer-reviewed science. Published in journals, taught in university labs, and translated into a supplement you can actually use.
Medical Advisory board
Every Berkeley Life formula is reviewed by physicians and researchers who treat patients every day — so what you take is grounded in practice, not just marketing.
4
CLINICAL SPECIALISTS
+ 60
YEARS COMBINED PRACTICE
3
BESTSELLING AUTHORS
Women's health evolves at every life stage. Berkeley Life makes nitric oxide support a simple part of a daily routine focused on healthy aging.
Why Nitric Oxide Matters.
Nitric Oxide acts as a signaling molecule throughout the body and supports communication across multiple physiological systems.
Blood pressure regulation & vascular function
Supports healthy brain blood flow and cognitive performance.
Assists with energy metabolism and cellular efficiency.
Promotes healthy blood flow throughout the body.
Supports the body's natural defense mechanisms.
Crucial for mitochondrial function and stamina.
Enhances nutrient delivery and waste removal in tissues.
Helps manage healthy inflammatory responses.
Facilitates signaling required for hormonal health.
Critical pathway for healthy physiological function.