Only a small percentage of dietary supplements are tested in gold-standard human clinical trials.
Berkeley Life® Nitric Oxide Support has been evaluated in double-blind, placebo-controlled research demonstrating its ability to increase nitric oxide bioavailability in humans.
The dietary nitrate ingredients used in our formulation are supported by a growing body of peer-reviewed clinical research validating improvements in vascular function, endothelial health, and blood pressure regulation.
The Impact of Clinical Proof
Double-blind, placebo-controlled trials (DBPCTs) are considered the gold standard in scientific research because they help ensure:
- Bias elimination
- Control for placebo effect
- Validated efficacy
- Safety and tolerability assessment
By studying the full nitrate formulation as it is consumed, Berkeley Life® ensures the product is evaluated for real-world effectiveness and safety - not just theoretical ingredient benefits.
Nitric Oxide Production
Berkeley Life® is formulated to increase nitric oxide through the dietary nitrate → nitrite → nitric oxide pathway.
Unlike L-arginine-based supplements, this pathway remains active even when endothelial nitric oxide synthase (eNOS) declines with age.
Clinical Trial Results
In a double-blind, placebo-controlled study, participants taking Berkeley Life® demonstrated significant increases in salivary nitrite and plasma nitrite compared to placebo. Test strip readings correlated with laboratory measurements, confirming improved nitric oxide bioavailability.
Vascular & Endothelial Health
Nitric oxide is essential for healthy blood vessel function. It supports vasodilation, circulation, and endothelial integrity - all of which naturally decline with age.
Clinical Trial Results
In clinical research evaluating dietary nitrate supplementation over 12 weeks, participants showed improvements in endothelial function and reductions in carotid artery stiffness, a recognized marker of cardiovascular risk. These findings support the role of nitrate-based nitric oxide in maintaining vascular flexibility and heart health.
Blood Pressure Support
Nitric oxide helps relax and widen blood vessels, supporting healthy blood pressure regulation.
Clinical Trial Results
Clinical studies of dietary nitrates have demonstrated improvements in systolic blood pressure and vascular responsiveness compared to placebo, particularly with consistent daily use over 8-12 weeks.
Energy & Oxygen Efficiency
Nitric oxide plays a critical role in oxygen delivery and mitochondrial signaling. Healthy nitric oxide levels support efficient energy production and muscle performance.
Clinical Research Findings
Research on dietary nitrates has shown improvements in oxygen utilization and exercise efficiency, including reduced oxygen cost during physical activity.
Aging & Nitric Oxide Decline
Nitric oxide production naturally declines with age due to oxidative stress, hormonal shifts, and reduced enzyme activity.
Berkeley Life® provides a nitrate-based pathway that supports nitric oxide production independently of age-related enzymatic decline, offering measurable vascular support as the body's natural production decreases.