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Nitric Oxide’s Vital Role in Female Sexual Health and Intimacy


Is Nitric Oxide an aphrodisiac? Let’s examine the ways it supports Female Sexual Health.
Part I of a 2 part sexual health series.

  • NO mediates functions critical for attaining and maintaining sexual excitement
    Nitric Oxide mediates the female genital arousal response that happens via sexual excitement as well as genital engorgement, swelling and lubrication.
  • NO controls clitoral and vaginal blood flow during sexual arousal
    Nitric Oxide is believed to have a primary role in the regulation of clitoral and vaginal blood flow, as well as smooth muscle relaxation during sexual arousal.
  • NO is a neurotransmitter that relaxes smooth muscle, leading to better blood flow and orgasms
    NO is a potent vasodilator of clitoral tissue. Sexual stimulation leads to NO production, which then relaxes smooth muscles in the clitoris to increase blood flow. Improved blood flow leads to better orgasms.
  • NO affects the release of hormones pivotal to sexual function and behavior
    Nitric Oxide affects reproductive processes both at the level of the brain and reproductive tract. NO acts as a neurotransmitter in the brain affecting the release of oxytocin and luteinizing hormone releasing hormones (LHRH) which help modulate sexual behavior.
  • NO levels work hand in hand with the “love hormone” oxytocin
    Oxytocin is called the “love hormone” or the “cuddle chemical.” Oxytocin increases NO production through the Nitric Oxide Synthase (NOS) enzyme system, and NO levels are greatly increased after orgasm.
  • NO leads to increased pleasure-enhancing lubrication
    During sexual arousal, NO is integral to vaginal smooth muscle relaxation and enhanced genital blood flow. It also modulates the release of fluid to enhance lubrication, which is essential for pleasurable coitus.
  • NO helps decrease anxiety, increase sexual pleasure, and enhance memory
    NO is an important neurotransmitter in decreasing anxiety, which increases sexual pleasure. NO is involved in the creation of long-term memory, and it enhances the ability to remember sex scents (pheromones) which are intimately related to libido.

Supporting Female Sexual Health and Intimacy